Okay, I've got a comment about .pngs v .gifs
While I was working on that last Lemmy comic, I wanted to make an effect. The blue stone Lemmy holds starts shining after he says a particular word.
These are actually the only two .png files I had in the entire Why? With a .gif, that effect came out horribly.

- PNG

- GIF
So, I guess if you're using fancy effects, .pngs are a good idea. But I'd do what I did and save most of the frames as .gifs and the "fancy" ones as .pngs if the effects come out crappy.

Where are these lemmings going? The
Super Nintendo Super Shire! Hop in line and follow them there!