^^Firstly, Amber and Wilson weren't married. Nice try.
Secondly, stereotypical? Really now?
Spoiler Below This is HOUSE AND WILSON. Wilson has a million separate reasons for hating House - and most of them, House doesn't care a lick about. Yet, Wilson sticks by him. This time around, however, House DOES care. It's going to be an interesting dynamic... besides, Wilson is dependent upon a person with a dominant personality like House's (why do you think he went for Amber?).
So, while the setup has been used before, it's never been employed this way before. Think about it - House and Wilson don't have a conventional relationship. I think the writer's are going to take the opportunity to really exploit that, because it has the opportunity for many delicious twists.